反应详情

In a manner similar to the method described in example 4a, 3-chloro-2-fluoro-6-hydroxy-benzaldehyde (2.07 g, 11.8 mmol) reacted with 4-(toluene-4-sulfonyloxy)-piperidine-1-carboxylic acid tert-butyl ester (3.51 g, 9.88 mmol, ASTATECH) and K2CO3 in N,N-dimethylformamide to give 4-(4-chloro-3-fluoro-2-formyl-phenoxy)-piperidine-1-carboxylic acid tert-butyl ester as a brown oil (Yield 3.75 g, 84%).