HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → (r/s)-3-(4-Bromo-2-formyl-phenoxy)-pyrrolidine-1-carboxylic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 5-Bromosalicylaldehyde | HCID 72863 | — |
| Reactant | (S)-1-Boc-3-methanesulfonyloxy-pyrrolidine | HCID 11032777 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | (r/s)-3-(4-Bromo-2-formyl-phenoxy)-pyrrolidine-1-carboxylic acid tert-butyl ester | HCID 57743437 | 54% |
Reaction Steps
In a manner similar to the method described in example 4a, 5-bromosalicylaldehyde (3.6 g, 18 mmol) (Aldrich) reacted with (S)-3-methanesulfonyloxy-pyrrolidine-1-carboxylic acid tert-butyl ester (5.3 g, 20 mmol) and K2CO3 in N,N-dimethylformamide to give (R/S)-3-(4-bromo-2-formyl-phenoxy)-pyrrolidine-1-carboxylic acid tert-butyl ester as an orange oil (Yield 3.6 g, 54%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08134001B2 |
| Source dataset | uspto-grants-2012_03 |
| ORD ID | ord-3026fba527cf4c96922155f334481352 |
| Source note | uspto-grants-2012_03 |