反应详情

In a manner similar to the method described in example 4a, 5-bromosalicylaldehyde (3.6 g, 18 mmol) (Aldrich) reacted with (S)-3-methanesulfonyloxy-pyrrolidine-1-carboxylic acid tert-butyl ester (5.3 g, 20 mmol) and K2CO3 in N,N-dimethylformamide to give (R/S)-3-(4-bromo-2-formyl-phenoxy)-pyrrolidine-1-carboxylic acid tert-butyl ester as an orange oil (Yield 3.6 g, 54%).