Imidazole → 2-{4-[2-(Tert-butyl-dimethyl-silanyloxy)-ethoxy]-phenoxy}-5-iodo-benzaldehyde

HRID 1095109노트

반응식

HRID 1095109 반응식
[OH:1][CH2:2][CH2:3][O:4][C:5]1[CH:20]=[CH:19][C:8]([O:9][C:10]2[CH:17]=[CH:16][C:15]([I:18])=[CH:14][C:11]=2[CH:12]=[O:13])=[CH:7][CH:6]=1.[C:21]([Si:25]([CH3:28])([CH3:27])Cl)([CH3:24])([CH3:23])[CH3:22].N1C=CN=C1>CN(C)C=O>[C:21]([Si:25]([CH3:28])([CH3:27])[O:1][CH2:2][CH2:3][O:4][C:5]1[CH:6]=[CH:7][C:8]([O:9][C:10]2[CH:17]=[CH:16][C:15]([I:18])=[CH:14][C:11]=2[CH:12]=[O:13])=[CH:19][CH:20]=1)([CH3:24])([CH3:23])[CH3:22]

참가 물질

5

반응물 3

HCID 795ImidazoleHCID 28928tert-Butyldimethylsilyl chlorideHCID 577433162-[4-(2-Hydroxy-ethoxy)-phenoxy]-5-iodo-benzaldehyde

생성물 1

HCID 577434172-{4-[2-(Tert-butyl-dimethyl-silanyloxy)-ethoxy]-phenoxy}-5-iodo-benzaldehyde수율 96.2%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

In a manner similar to the method described in Example 60b, 2-[4-(2-hydroxy-ethoxy)-phenoxy]-5-iodo-benzaldehyde (3.8 g, 9.8 mmol) was reacted with tert-butyldimethylchlorosilane (1.8 g, 12 mmol) and imidazole in N,N-dimethylformamide to give 2-{4-[2-(tert-butyl-dimethyl-silanyloxy)-ethoxy]-phenoxy}-5-iodo-benzaldehyde as a white solid (Yield 4.7 g, 95%).

출처 및 근거

ORD 기록
ord-6a6b93645d1d45cbb453bb70b0006815
출처 데이터셋
uspto-grants-2012_03
특허 번호
US08134001B2

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