HuagongsheHuagongshe Chemistry Print Report · For research reference only
Imidazole → 2-{4-[2-(Tert-butyl-dimethyl-silanyloxy)-ethoxy]-phenoxy}-5-iodo-benzaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Imidazole | HCID 795 | — |
| Reactant | tert-Butyldimethylsilyl chloride | HCID 28928 | — |
| Reactant | 2-[4-(2-Hydroxy-ethoxy)-phenoxy]-5-iodo-benzaldehyde | HCID 57743316 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-{4-[2-(Tert-butyl-dimethyl-silanyloxy)-ethoxy]-phenoxy}-5-iodo-benzaldehyde | HCID 57743417 | 96.2% |
Reaction Steps
In a manner similar to the method described in Example 60b, 2-[4-(2-hydroxy-ethoxy)-phenoxy]-5-iodo-benzaldehyde (3.8 g, 9.8 mmol) was reacted with tert-butyldimethylchlorosilane (1.8 g, 12 mmol) and imidazole in N,N-dimethylformamide to give 2-{4-[2-(tert-butyl-dimethyl-silanyloxy)-ethoxy]-phenoxy}-5-iodo-benzaldehyde as a white solid (Yield 4.7 g, 95%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08134001B2 |
| Source dataset | uspto-grants-2012_03 |
| ORD ID | ord-6a6b93645d1d45cbb453bb70b0006815 |
| Source note | uspto-grants-2012_03 |