Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Imidazole → 2-{4-[2-(Tert-butyl-dimethyl-silanyloxy)-ethoxy]-phenoxy}-5-chloro-benzaldehyde
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Imidazole | HCID 795 | — |
| 반응물 | tert-Butyldimethylsilyl chloride | HCID 28928 | — |
| 반응물 | 5-Chloro-2-[4-(2-hydroxy-ethoxy)-phenoxy]-benzaldehyde | HCID 57743421 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 2-{4-[2-(Tert-butyl-dimethyl-silanyloxy)-ethoxy]-phenoxy}-5-chloro-benzaldehyde | HCID 57743299 | 90.5% |
반응 단계
In a manner similar to the method described in Example 60b, 5-chloro-2-[4-(2-hydroxy-ethoxy)-phenoxy]-benzaldehyde (1.68 g, 5.7 mmol) was reacted with tert-butyldimethylchlorosilane (1.3 g, 8.6 mmol) and imidazole in N,N-dimethylformamide to give 2-{4-[2-(tert-butyl-dimethyl-silanyloxy)-ethoxy]-phenoxy}-5-chloro-benzaldehyde as a white solid (Yield 2.1 g, 90%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08134001B2 |
| 출처 데이터셋 | uspto-grants-2012_03 |
| ORD ID | ord-a690234d69c84cc1943ce30ac862d341 |
| 출처 메모 | uspto-grants-2012_03 |