HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 2-(2,6-Dimethyl-pyridin-4-yloxy)-5-iodo-benzaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-Fluoro-5-iodobenzaldehyde | HCID 16217058 | — |
| Reactant | HCID 178429033 | HCID 178429033 | — |
| Solvent | Dimethylacetamide | HCID 31374 | — |
| Product | 2-(2,6-Dimethyl-pyridin-4-yloxy)-5-iodo-benzaldehyde | HCID 57743403 | 93.1% |
Reaction Steps
In a manner similar to the method described in Example 50a, 2-fluoro-5-iodobenzaldehyde (2 g, 8 mmol) (Aldrich) was reacted with 2,6-dimethyl-4-hydroxypyridine (1.08 g, 8.8 mmol) and K2CO3 in N,N-dimethylacetamide to give 2-(2,6-dimethyl-pyridin-4-yloxy)-5-iodo-benzaldehyde as a yellow solid (Yield 2.63 g, 92%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08134001B2 |
| Source dataset | uspto-grants-2012_03 |
| ORD ID | ord-e07553be561d4a1f848598f1fc425f93 |
| Source note | uspto-grants-2012_03 |