反应详情

In a manner similar to the methods described in Examples 1a and 1b, 6-chloro-1,3-dihydro-indol-2-one (Aldrich) reacted with 2-chloro-5-trifluoromethyl-benzaldehyde (Aldrich) to give 6-chloro-3-[1-(2-chloro-5-trifluoromethyl-phenyl)-methylidene]-2-oxo-2,3-dihydro-indole, which was subsequently reacted with di-tert-butyl-dicarbonate and DMAP and directly used for the next step.