Phosphorus oxychloride → 1-(3-Benzyloxyphenyl)-3-tert-butylimidazo[1,5-a]pyrazin-8-ylamine

HRID 109524Notes

Reaction equation

HRID 109524 reaction equation
[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][c:9]1[cH:10][c:11](-[c:15]2[n:16][c:17]([C:25]([CH3:26])([CH3:27])[CH3:28])[n:18]3[c:19]2[c:20]([Cl:24])[n:21][cH:22][cH:23]3)[cH:12][cH:13][cH:14]1.[CH2:34]([O:35][c:36]1[cH:37][c:38]([CH:39]([c:40]2[c:41]([Cl:42])[n:43][cH:44][cH:45][n:46]2)[NH:49][C:47](=[O:48])[C:50]([CH3:51])([CH3:52])[CH3:53])[cH:54][cH:55][cH:56]1)[c:57]1[cH:58][cH:59][cH:60][cH:61][cH:62]1.[P:29]([Cl:30])([Cl:31])([Cl:32])=[O:33]>>[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][c:9]1[cH:10][c:11](-[c:15]2[n:16][c:17]([C:25]([CH3:26])([CH3:27])[CH3:28])[n:18]3[c:19]2[c:20]([NH2:49])[n:21][cH:22][cH:23]3)[cH:12][cH:13][cH:14]1

Participants

4

Reactant 3

HCID 24813Phosphorus oxychlorideHCID 59852773N-[(3-benzyloxyphenyl)-(3-chloropyrazin-2-yl)-methyl]-2,2-dimethylpropionamideHCID 598527951-(3-Benzyloxyphenyl)-3-tert-butyl-8-chloroimidazo[1,5-a]pyrazine

Product 1

HCID 112802111-(3-Benzyloxyphenyl)-3-tert-butylimidazo[1,5-a]pyrazin-8-ylamine

Sources & evidence

ORD record
ord-83736970db2945e6aff3a275a0f604b4
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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