Hydrochloric Acid → L-Serine, methyl ester, hydrochloride (1:1)

HRID 1095262Notes

Reaction equation

HRID 1095262 reaction equation
[NH2:1][C@@H:2]([C:5]([OH:7])=[O:6])[CH2:3][OH:4].[ClH:8].[CH3:9]O>>[ClH:8].[CH3:9][O:6][C:5](=[O:7])[C@H:2]([CH2:3][OH:4])[NH2:1]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 71077D-Serine

Product 1

HCID 2723730L-Serine, methyl ester, hydrochloride (1:1)Yield 99%

Procedure

A solution of 47.7 mmol of D-serine in 476 ml of methanol was saturated with hydrochloric acid gas and allowed to react at room temperature for 2 hrs. Following the evaporation of the solvent, recrystallization with methanol and ether produced the object compound L-serine methyl ester hydrochloric acid salt (Yield: 99%, m.p.: 163-164° C., [α]25 D=−4.3(c 1.8, EtOH)). The structure of the synthesized compound was identified using FTIR, 1H-NMR and 13C-NMR.

Workup

  1. customto react at room temperature for 2 hrs
  2. customthe evaporation of the solvent, recrystallization with methanol and ether

Sources & evidence

ORD record
ord-cfc37f1ebab0461aa5d8090b9d945a4e
Source dataset
uspto-grants-2012_03
Patent number
US08137970B2

Reaction notes

Loading…