Trifluoroacetic acid → HCID 24962065, compound

HRID 1095335Notes

Reaction equation

HRID 1095335 reaction equation
[NH2:1][C:2]1[N:10]=[C:9]([O:11][CH2:12][CH2:13][CH2:14][CH3:15])[N:8]=[C:7]2[C:3]=1[NH:4][C:5](=[O:43])[N:6]2[CH2:16][CH2:17][CH2:18][N:19]([CH2:31][C:32]1[CH:37]=[CH:36][CH:35]=[C:34]([CH2:38][C:39]([O:41][CH3:42])=[O:40])[CH:33]=1)[C:20](=[O:30])[CH2:21][CH2:22][C:23]([O:25]C(C)(C)C)=[O:24].C(O)(C(F)(F)F)=O>C(Cl)Cl>[NH2:1][C:2]1[N:10]=[C:9]([O:11][CH2:12][CH2:13][CH2:14][CH3:15])[N:8]=[C:7]2[C:3]=1[NH:4][C:5](=[O:43])[N:6]2[CH2:16][CH2:17][CH2:18][N:19]([CH2:31][C:32]1[CH:37]=[CH:36][CH:35]=[C:34]([CH2:38][C:39]([O:41][CH3:42])=[O:40])[CH:33]=1)[C:20](=[O:30])[CH2:21][CH2:22][C:23]([OH:25])=[O:24]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 24962064HCID 24962064, compound

Product 1

HCID 24962065HCID 24962065, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The product from example 18 (140 mg) was dissolved in DCM (1 ml) and TFA (0.2 ml) added. The mixture was stirred at rt for 2 h. The solution was washed with saturated aqueous NaHCO3 solution and dried. The mixture was purified by RPHPLC, which afforded the title compound. Yield 80 mg.

Workup

  1. washThe solution was washed with saturated aqueous NaHCO3 solution
  2. customdried
  3. customThe mixture was purified by RPHPLC, which

Sources & evidence

ORD record
ord-1c5d493137d54ad5a1c9eef8c4880590
Source dataset
uspto-grants-2012_03
Patent number
US08138172B2

Reaction notes

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