HRID1095335

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6422

未命名化合物

结构：CCCCOc1nc(N)c2[nH]c(=O)n(CCCN(Cc3cccc(CC(=O)OC)c3)C(=O)CCC(=O)OC(C)(C)C)c2n1

HCID24962064

未命名化合物

PRODUCTS

生成物

结构：CCCCOc1nc(N)c2[nH]c(=O)n(CCCN(Cc3cccc(CC(=O)OC)c3)C(=O)CCC(=O)O)c2n1

HCID24962065

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

The product from example 18 (140 mg) was dissolved in DCM (1 ml) and TFA (0.2 ml) added. The mixture was stirred at rt for 2 h. The solution was washed with saturated aqueous NaHCO3 solution and dried. The mixture was purified by RPHPLC, which afforded the title compound. Yield 80 mg.

WORKUP

后处理

washThe solution was washed with saturated aqueous NaHCO3 solution
customdried
customThe mixture was purified by RPHPLC, which

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-1c5d493137d54ad5a1c9eef8c4880590
来源数据集: uspto-grants-2012_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08138172B2
来源说明: uspto-grants-2012_03

反应 SMILES

[NH2:1][C:2]1[N:10]=[C:9]([O:11][CH2:12][CH2:13][CH2:14][CH3:15])[N:8]=[C:7]2[C:3]=1[NH:4][C:5](=[O:43])[N:6]2[CH2:16][CH2:17][CH2:18][N:19]([CH2:31][C:32]1[CH:37]=[CH:36][CH:35]=[C:34]([CH2:38][C:39]([O:41][CH3:42])=[O:40])[CH:33]=1)[C:20](=[O:30])[CH2:21][CH2:22][C:23]([O:25]C(C)(C)C)=[O:24].C(O)(C(F)(F)F)=O>C(Cl)Cl>[NH2:1][C:2]1[N:10]=[C:9]([O:11][CH2:12][CH2:13][CH2:14][CH3:15])[N:8]=[C:7]2[C:3]=1[NH:4][C:5](=[O:43])[N:6]2[CH2:16][CH2:17][CH2:18][N:19]([CH2:31][C:32]1[CH:37]=[CH:36][CH:35]=[C:34]([CH2:38][C:39]([O:41][CH3:42])=[O:40])[CH:33]=1)[C:20](=[O:30])[CH2:21][CH2:22][C:23]([OH:25])=[O:24]