HRID1095336

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID313

Hydrochloric Acid

ClH

结构：CCCCOc1nc(N)c2[nH]c(=O)n(CCCN(Cc3cccc(CC(=O)OC)c3)C(=O)CC(=O)OC(C)(C)C)c2n1

HCID86645626

未命名化合物

PRODUCTS

生成物

结构：CCCCOc1nc(N)c2[nH]c(=O)n(CCCN(Cc3cccc(CC(=O)OC)c3)C(=O)CC(=O)OC)c2n1

HCID24962426

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID887

Methanol

CH4O

溶剂HCID31275

1,4-Dioxane

C4H8O2

PROCEDURE

实验过程

The product from step (i) (100 mg) was dissolved in methanol (3 ml) and 4N—HCl in dioxane added. The mixture was stirred at rt for 5 h and purified by RPHPLC, which afforded the title compound. Yield 80 mg

WORKUP

后处理

custompurified by RPHPLC, which

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-07c4f486a942446ab43263629178e7fc
来源数据集: uspto-grants-2012_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08138172B2
来源说明: uspto-grants-2012_03

反应 SMILES

[NH2:1][C:2]1[N:10]=[C:9]([O:11][CH2:12][CH2:13][CH2:14][CH3:15])[N:8]=[C:7]2[C:3]=1[NH:4][C:5](=[O:42])[N:6]2[CH2:16][CH2:17][CH2:18][N:19]([CH2:30][C:31]1[CH:36]=[CH:35][CH:34]=[C:33]([CH2:37][C:38]([O:40][CH3:41])=[O:39])[CH:32]=1)[C:20](=[O:29])[CH2:21][C:22]([O:24][C:25](C)(C)C)=[O:23].Cl>CO.O1CCOCC1>[NH2:1][C:2]1[N:10]=[C:9]([O:11][CH2:12][CH2:13][CH2:14][CH3:15])[N:8]=[C:7]2[C:3]=1[NH:4][C:5](=[O:42])[N:6]2[CH2:16][CH2:17][CH2:18][N:19]([CH2:30][C:31]1[CH:36]=[CH:35][CH:34]=[C:33]([CH2:37][C:38]([O:40][CH3:41])=[O:39])[CH:32]=1)[C:20](=[O:29])[CH2:21][C:22]([O:24][CH3:25])=[O:23]