HRID1095338

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID557

1-methylpyrrolidine-2-carboxylic acid

C6H11NO2

结构：CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F

HCID9886157

Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)

C10H15F6N6OP

结构：CCCCOc1nc(N)c2[nH]c(=O)n(CCCNCc3ccc(CC(=O)OC)cc3)c2n1

HCID90697362

未命名化合物

PRODUCTS

生成物

结构：CCCCOc1nc(N)c2[nH]c(=O)n(CCCN(Cc3ccc(CC(=O)OC)cc3)C(=O)[C@@H]3CCCN3C)c2n1

HCID59492376

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

The product of example 1, step (ix) (0.43 g), 1-methyl-pyrrolidine-2-carboxylic acid (0.13 g) and HATU (0.37 g) were stirred in DCM (5 ml) at rt for 7 days. The reaction mixture was purified by SCX and RPHPLC, to give the title compound. Yield 24 mg.

WORKUP

后处理

customThe reaction mixture was purified by SCX and RPHPLC

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-8e036efb534b4b5c9b1d856560ab0f39
来源数据集: uspto-grants-2012_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08138172B2
来源说明: uspto-grants-2012_03

反应 SMILES

[CH3:1][O:2][C:3](=[O:32])[CH2:4][C:5]1[CH:10]=[CH:9][C:8]([CH2:11][NH:12][CH2:13][CH2:14][CH2:15][N:16]2[C:24](=[O:25])[NH:23][C:22]3[C:17]2=[N:18][C:19]([O:27][CH2:28][CH2:29][CH2:30][CH3:31])=[N:20][C:21]=3[NH2:26])=[CH:7][CH:6]=1.[CH3:33][N:34]1[CH2:38][CH2:37][CH2:36][CH:35]1[C:39](O)=[O:40].CN(C(ON1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F>C(Cl)Cl>[CH3:1][O:2][C:3](=[O:32])[CH2:4][C:5]1[CH:10]=[CH:9][C:8]([CH2:11][N:12]([CH2:13][CH2:14][CH2:15][N:16]2[C:24](=[O:25])[NH:23][C:22]3[C:17]2=[N:18][C:19]([O:27][CH2:28][CH2:29][CH2:30][CH3:31])=[N:20][C:21]=3[NH2:26])[C:39]([C@@H:35]2[CH2:36][CH2:37][CH2:38][N:34]2[CH3:33])=[O:40])=[CH:7][CH:6]=1