HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Methylpyrrolidine-2-carboxylic acid → (4-{[[3-(6-Amino-2-butoxy-8-oxo-7,8-dihydro-purin-9-yl)-propyl][2S]-(1-methyl-pyrrolidine-2-carbonyl)-amino]-methyl}-phenyl)-acetic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Methylpyrrolidine-2-carboxylic acid | HCID 557 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | Methyl[4-({[3-(6-amino-2-butoxy-8-oxo-7,8-dihydro-9H-purin-9-yl)propyl]amino}methyl)phenyl]acetate | HCID 90697362 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (4-{[[3-(6-Amino-2-butoxy-8-oxo-7,8-dihydro-purin-9-yl)-propyl][2S]-(1-methyl-pyrrolidine-2-carbonyl)-amino]-methyl}-phenyl)-acetic acid methyl ester | HCID 59492376 | — |
Reaction Steps
The product of example 1, step (ix) (0.43 g), 1-methyl-pyrrolidine-2-carboxylic acid (0.13 g) and HATU (0.37 g) were stirred in DCM (5 ml) at rt for 7 days. The reaction mixture was purified by SCX and RPHPLC, to give the title compound. Yield 24 mg.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08138172B2 |
| Source dataset | uspto-grants-2012_03 |
| ORD ID | ord-8e036efb534b4b5c9b1d856560ab0f39 |
| Source note | uspto-grants-2012_03 |