Ammonium Hydroxide → HCID 57446212, compound

Participants

Reaction Conditions

Reaction Steps

2-Ethyl-4-oxo-4,5-dihydro-2H-pyrazolo[3,4-c]quinoline-1-carbaldehyde (1 g) was combined with phosphorus oxychloride (10 mL) and heated at 100° C. for 30 minutes. The reaction mixture was cooled to ambient temperature, poured into a mixture of ammonium hydroxide and ice, and then stirred for 20 minutes. A solid was isolated by filtration and air dried to provide 4-chloro-2-ethyl-2H-pyrazolo[3,4-c]quinoline-1-carbaldehyde as a white powder. MS (APCI) m/z 260 (M+H)+.

Provenance & Evidence