Ammonium Hydroxide → HCID 57446212, compound

HRID 1095345Notes

Reaction equation

HRID 1095345 reaction equation
[CH2:1]([N:3]1[C:15]([CH:16]=[O:17])=[C:14]2[C:5]([C:6](=O)[NH:7][C:8]3[CH:9]=[CH:10][CH:11]=[CH:12][C:13]=32)=[N:4]1)[CH3:2].[OH-].[NH4+].P(Cl)(Cl)([Cl:23])=O>>[Cl:23][C:6]1[C:5]2=[N:4][N:3]([CH2:1][CH3:2])[C:15]([CH:16]=[O:17])=[C:14]2[C:13]2[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=2[N:7]=1

Participants

4

Reactant 3

HCID 14923Ammonium HydroxideHCID 24813Phosphorus oxychlorideHCID 16723630HCID 16723630, compound

Product 1

HCID 57446212HCID 57446212, compound

Conditions

Temperature
100 °C

Procedure

2-Ethyl-4-oxo-4,5-dihydro-2H-pyrazolo[3,4-c]quinoline-1-carbaldehyde (1 g) was combined with phosphorus oxychloride (10 mL) and heated at 100° C. for 30 minutes. The reaction mixture was cooled to ambient temperature, poured into a mixture of ammonium hydroxide and ice, and then stirred for 20 minutes. A solid was isolated by filtration and air dried to provide 4-chloro-2-ethyl-2H-pyrazolo[3,4-c]quinoline-1-carbaldehyde as a white powder. MS (APCI) m/z 260 (M+H)+.

Workup

  1. temperatureThe reaction mixture was cooled to ambient temperature
  2. customA solid was isolated by filtration and air
  3. customdried

Sources & evidence

ORD record
ord-f6caa648c4d54516bd6ac4c0219592ab
Source dataset
uspto-grants-2012_03
Patent number
US08138173B2

Reaction notes

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