Formaldehyde → HCID 57446233, compound

HRID 1095368Notes

Reaction equation

HRID 1095368 reaction equation
[C:1]([N:5]1[CH:17]=[C:16]2[C:7]([C:8](=[O:18])[NH:9][C:10]3[CH:11]=[CH:12][CH:13]=[CH:14][C:15]=32)=[N:6]1)([CH3:4])([CH3:3])[CH3:2].C([Li])CCC.[CH2:24]=[O:25].[Cl-].[NH4+]>O1CCCC1.CN(C)CCN(C)C>[C:1]([N:5]1[C:17]([CH2:24][OH:25])=[C:16]2[C:7]([C:8](=[O:18])[NH:9][C:10]3[CH:11]=[CH:12][CH:13]=[CH:14][C:15]=32)=[N:6]1)([CH3:4])([CH3:2])[CH3:3]

Participants

7

Reactant 4

HCID 712Formaldehyde2×HCID 25517Ammonium ChlorideHCID 10776486HCID 10776486, compoundHCID 178418339Butyllithium

Product 1

HCID 57446233HCID 57446233, compoundYield 44.5%

Reagents, catalysts & solvents 2

HCID 8028TetrahydrofuranSolventHCID 8037N,N,N',N'-TetramethylethylenediamineSolvent

Procedure

A stirring solution of 2-tert-butyl-2,5-dihydro-4H-pyrazolo[3,4-c]quinolin-4-one (10.0 g, 41.4 mmol) in tetrahydrofuran (400 mL) and N,N,N′,N′ tetramethylethylenediamine (28 mL) was placed under an atmosphere of nitrogen and cooled to 0° C. n-Butyllithium (2.5M solution in hexanes, 49.7 mL, 124 mmol) was added dropwise over 30 minutes via an addition funnel. The resulting suspension was stirred at 0° C. for 15 minutes at which point paraformaldehyde (10.0 g, 333 mmol) was added in portions over 2 minutes. The suspension was allowed to warm to ambient temperature and stir for 2 hours. Additional paraformaldehyde (5.0 g, 167 mmol) was added and the resulting suspension stirred for 1.5 hours. Saturated aqueous ammonium chloride (150 mL) was added carefully and the mixture transferred to a separatory funnel. The aqueous layer was extracted with dichloromethane (3×150 mL). The combined organic layers were concentrated to a brown solid which was triturated with acetonitrile (100 mL). The solid was isolated by filtration and the filter cake was washed with additional acetonitrile (100 mL). The cake was dried in a vacuum oven at 65° C. overnight to yield 5.0 g of 2-tert-butyl-1-(hydroxymethyl)-2,5-dihydro-4H-pyrazolo[3,4-c]quinolin-4-one as a tan solid. 500 mg of this material was crystallized from hot acetonitrile (100 mL) and isolated by filtration to yield 288 mg of 2-tert-butyl-1-(hydroxymethyl)-2,5-dihydro-4H-pyrazolo[3,4-c]quinolin-4-one as a tan solid, mp 295-297° C. Anal. calcd for C15H17N3O2: C, 66.40; H, 6.32; N, 15.49. Found: C, 66.26; H, 6.64; N, 15.54.

Workup

  1. additionwas added dropwise over 30 minutes via an addition funnel
  2. additionwas added in portions over 2 minutes
  3. stirringthe resulting suspension stirred for 1.5 hours
  4. customthe mixture transferred to a separatory funnel
  5. extractionThe aqueous layer was extracted with dichloromethane (3×150 mL)
  6. concentrationThe combined organic layers were concentrated to a brown solid which
  7. customwas triturated with acetonitrile (100 mL)
  8. customThe solid was isolated by filtration
  9. washthe filter cake was washed with additional acetonitrile (100 mL)
  10. customThe cake was dried in a vacuum oven at 65° C. overnight

Sources & evidence

ORD record
ord-b4b4e465a9b24a3d8af354f346a0a195
Source dataset
uspto-grants-2012_03
Patent number
US08138173B2

Reaction notes

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