Hydrochloric Acid → HCID 66781746, compound

HRID 1095376Notes

Reaction equation

HRID 1095376 reaction equation
[O:1]=[C:2]1[C:11]2=[N:12][N:13]([C:31]3[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=3)[C:14]([CH2:15][C:16]([N:18]3[CH2:23][CH2:22][N:21](C(OC(C)(C)C)=O)[CH2:20][CH2:19]3)=[O:17])=[C:10]2[C:9]2[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=2[NH:3]1.Cl>C(O)C>[O:17]=[C:16]([N:18]1[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]1)[CH2:15][C:14]1[N:13]([C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)[N:12]=[C:11]2[C:10]=1[C:9]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[NH:3][C:2]2=[O:1]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 57446245tert-butyl 4-[(4-oxo-2-phenyl-4,5-dihydro-2H-pyrazolo[3,4-c]quinolin-1-yl)acetyl]piperazine-1-carboxylate

Product 1

HCID 66781746HCID 66781746, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
60 °C

Procedure

A mixture of tert-butyl 4-[(4-oxo-2-phenyl-4,5-dihydro-2H-pyrazolo[3,4-c]quinolin-1-yl)acetyl]piperazine-1-carboxylate, 4 mL of 6 N aqueous hydrochloric acid, and 12 mL of ethanol was heated at 60° C. for 5 hours. The mixture was allowed to cool to ambient temperature and was concentrated under reduced pressure. The residue was triturated with acetonitrile, isolated by filtration, and dried to afford 1.60 g of 1-(2-oxo-2-piperazin-1-ylethyl)-2-phenyl-2,5-dihydro-4H-pyrazolo[3,4-c]quinolin-4-one; hydrochloride as a white solid.

Workup

  1. temperatureto cool to ambient temperature
  2. concentrationwas concentrated under reduced pressure
  3. customThe residue was triturated with acetonitrile
  4. customisolated by filtration
  5. customdried

Sources & evidence

ORD record
ord-12d006ab18454fa7b50d2ef833293080
Source dataset
uspto-grants-2012_03
Patent number
US08138173B2

Reaction notes

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