反应详情

温度

60 °C

A mixture of tert-butyl 4-[(4-oxo-2-phenyl-4,5-dihydro-2H-pyrazolo[3,4-c]quinolin-1-yl)acetyl]piperazine-1-carboxylate, 4 mL of 6 N aqueous hydrochloric acid, and 12 mL of ethanol was heated at 60° C. for 5 hours. The mixture was allowed to cool to ambient temperature and was concentrated under reduced pressure. The residue was triturated with acetonitrile, isolated by filtration, and dried to afford 1.60 g of 1-(2-oxo-2-piperazin-1-ylethyl)-2-phenyl-2,5-dihydro-4H-pyrazolo[3,4-c]quinolin-4-one; hydrochloride as a white solid.

1. temperatureto cool to ambient temperature
2. concentrationwas concentrated under reduced pressure
3. customThe residue was triturated with acetonitrile
4. customisolated by filtration
5. customdried