反应详情

As described in Scheme 1, treatment of 7-hydroxy-3-(4-methoxyphenyl)-4H-chromen-4-one (1) with 2-bromopropane gives 3-(4-methoxyphenyl)-7-isopropoxy-4H-chromen-4-one (2) which is then reacted with NH2OH to give 5-isopropoxy-2-(4-(4-methoxyphenyl)isoxazol-5-yl)phenol (3) in a good overall yield. Reaction of 3 with polyethylenedibromide affords monobromoisoxazoles 4 which are respectively treated with substituted amines to afford the respective aminoalkoxy substituted 4,5-diphenylisokazoles 5.