2-(4-Aminophenyl)ethylamine → N-(4-aminophenethyl)-5,6-diphenylfuro[2,3-d]pyrimidin-4-amine

HRID 1095471노트

반응식

HRID 1095471 반응식
Cl[C:2]1[C:3]2[C:10]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)=[C:9]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[O:8][C:4]=2[N:5]=[CH:6][N:7]=1.[NH2:23][CH2:24][CH2:25][C:26]1[CH:32]=[CH:31][C:29]([NH2:30])=[CH:28][CH:27]=1>C(O)CCC>[NH2:30][C:29]1[CH:31]=[CH:32][C:26]([CH2:25][CH2:24][NH:23][C:2]2[C:3]3[C:10]([C:11]4[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=4)=[C:9]([C:17]4[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=4)[O:8][C:4]=3[N:5]=[CH:6][N:7]=2)=[CH:27][CH:28]=1

참가 물질

4

반응물 2

HCID 728952-(4-Aminophenyl)ethylamineHCID 114496374-Chloro-5,6-diphenylfuro[2,3-d]pyrimidine

생성물 1

HCID 46855043N-(4-aminophenethyl)-5,6-diphenylfuro[2,3-d]pyrimidin-4-amine수율 74%

시약·촉매·용매 1

HCID 2631-Butanol용매

실험 절차

4-Chloro-5,6-diphenylfuro[2,3-d]pyrimidine (0.200 g) and 4-(2-aminoethyl)aniline (0.107 g) in n-butanol (5 mL) were heated at 80° C. for 16 h. The reaction mixture was concentrated and the residue was partitioned between water and ethyl acetate. The organic layer was concentrated and the crude compound was purified by silica gel column chromatography using a mixture of dichloromethane:methanol (40:1), to give N-(4-aminophenethyl)-5,6-diphenylfuro[2,3-d]pyrimidin-4-amine (0.195 g, 74%).

후처리

  1. concentrationThe reaction mixture was concentrated
  2. customthe residue was partitioned between water and ethyl acetate
  3. concentrationThe organic layer was concentrated
  4. customthe crude compound was purified by silica gel column chromatography
  5. additiona mixture of dichloromethane:methanol (40:1)

출처 및 근거

ORD 기록
ord-df27339b0eb54779996fe49ae54f0d63
출처 데이터셋
uspto-grants-2012_03
특허 번호
US08138194B2

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