HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 2-[2-(1H-indol-3-yl)ethyl]-1H-Isoindole-1,3(2H)-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Tryptamine | HCID 1150 | — |
| Reactant | Phthalic Anhydride | HCID 6811 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 2-[2-(1H-indol-3-yl)ethyl]-1H-Isoindole-1,3(2H)-dione | HCID 288577 | — |
Reaction Steps
A solution of tryptamine (3.04 g, 19.0 mmol) and phthalic anhydride (3.0 g, 20.0 mmol) in toluene (300 ml) was boiled under reflux for 12 h using a water separator. The solvent was removed i. vac. and the residue was recrystallized from methylene chloride/cyclohexane. Yield: 4.46 g (81%)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08138187B2 |
| Source dataset | uspto-grants-2012_03 |
| ORD ID | ord-10e4f6e9b27f4f91a28a43a56083ab90 |
| Source note | uspto-grants-2012_03 |