反应详情

A solution of 3-(2-bromo-ethyl)-5-fluoro-1H-indole (7.26 g, 30 mmol), benz-imidazole (3.54 g, 30 mmol) and ethyl-diisopropylamine (5.1 ml, 30 mmol) in abs. chloroform (80 ml) was boiled under reflux for 20 h. The reaction solution was then washed twice with water, dried over Na2SO4 and concentrated i. vac. and the residue which remained was purified by flash chromatography with CHCl3/MeOH (50:1).

1. temperatureunder reflux for 20 h
2. washThe reaction solution was then washed twice with water
3. dry with materialdried over Na2SO4
4. concentrationconcentrated i
5. customand the residue which remained was purified by flash chromatography with CHCl3/MeOH (50:1)