反应详情

A solution of 3-(2-bromo-ethyl)-5-fluoro-1H-indole (7.26 g, 30 mmol), 1,2,3-triazole (2.07 g, 30 mmol) and ethyl-diisopropylamine (5.1 ml, 30 mmol) in abs. chloroform (70 ml) was boiled under reflux for 24 h. The reaction solution was then washed twice with water, dried over Na2SO4 and concentrated i. vac. and the residue which remained was purified by flash chromatography with EA/cyclohexane (1:1→4:1).).

1. temperatureunder reflux for 24 h
2. washThe reaction solution was then washed twice with water
3. dry with materialdried over Na2SO4
4. concentrationconcentrated i
5. customand the residue which remained was purified by flash chromatography with EA/cyclohexane (1:1→4:1)