反应详情

A solution of 3-(2-bromo-ethyl)-5-fluoro-1H-indole (4.84 g, 20 mmol), imidazole (1.36 g, 20 mmol) and ethyl-diisopropylamine (3.4 ml, 20 mmol) in abs. dioxane (50 ml) was stirred at 90° C. for 8 h until according to TLC educt was no longer present. The solvent was then removed i. vac., CHCl3 (100 ml) was added to the residue and the organic phase was washed twice with water. The organic phase was dried over Na2SO4 and concentrated i. vac. and the residue which remained was purified by flash chromatography with CHCl3/MeOH (9:1).

1. customThe solvent was then removed i
2. addition, CHCl3 (100 ml) was added to the residue
3. washthe organic phase was washed twice with water
4. dry with materialThe organic phase was dried over Na2SO4
5. concentrationconcentrated i
6. customand the residue which remained was purified by flash chromatography with CHCl3/MeOH (9:1)