Chlorotrimethylsilane → HCID 66783240, compound

Participants

Reaction Steps

1-Butyl-N,N-dimethyl-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)cyclohexanamine (425 mg, 1.42 mmol) was dissolved in ethyl acetate (100 ml). Me3SiCl (358 μl, 2.84 mmol) was then added dropwise at RT and the mixture was stirred for 1 h. A white precipitate precipitated out. The precipitate was filtered off with suction, washed with ethyl acetate (2×10 ml) and then dried. Example 238 (435 mg, 91%) was a colourless solid

Provenance & Evidence