Chlorotrimethylsilane → HCID 66783240, compound

HRID 1095594Notes

Reaction equation

HRID 1095594 reaction equation
[CH2:1]([C:5]1([N:20]([CH3:22])[CH3:21])[CH2:10][CH2:9][CH:8]([C:11]2[C:19]3[C:14](=[N:15][CH:16]=[CH:17][CH:18]=3)[NH:13][CH:12]=2)[CH2:7][CH2:6]1)[CH2:2][CH2:3][CH3:4].[Si]([Cl:27])(C)(C)C>C(OCC)(=O)C>[ClH:27].[CH2:1]([C:5]1([N:20]([CH3:22])[CH3:21])[CH2:6][CH2:7][CH:8]([C:11]2[C:19]3[C:14](=[N:15][CH:16]=[CH:17][CH:18]=3)[NH:13][CH:12]=2)[CH2:9][CH2:10]1)[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 2

HCID 6397ChlorotrimethylsilaneHCID 66783214HCID 66783214, compound

Product 1

HCID 66783240HCID 66783240, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

1-Butyl-N,N-dimethyl-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)cyclohexanamine (425 mg, 1.42 mmol) was dissolved in ethyl acetate (100 ml). Me3SiCl (358 μl, 2.84 mmol) was then added dropwise at RT and the mixture was stirred for 1 h. A white precipitate precipitated out. The precipitate was filtered off with suction, washed with ethyl acetate (2×10 ml) and then dried. Example 238 (435 mg, 91%) was a colourless solid

Workup

  1. customA white precipitate precipitated out
  2. filtrationThe precipitate was filtered off with suction
  3. washwashed with ethyl acetate (2×10 ml)
  4. customdried

Sources & evidence

ORD record
ord-e315e539f3e14ce6b19990d8908a74d8
Source dataset
uspto-grants-2012_03
Patent number
US08138187B2

Reaction notes

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