反应详情

Ethyl 2-chloro-3-oxopropanoate (5.1 g, 33.9 mmol, Heterocycles 1991, pg. 699) and 4-(2-methoxyethoxy)pyridin-2-amine (5.70 g, 33.9 mmol) was dissolved in EtOH (50 mL) and heated to reflux overnight. The crude reaction mixture was concentrated and purified by flash column chromatography (EtOAc/MeOH 10:0 to 10:1) provided the desired product (57%).

1. temperatureheated
2. temperatureto reflux overnight
3. customThe crude reaction mixture
4. concentrationwas concentrated
5. custompurified by flash column chromatography (EtOAc/MeOH 10:0 to 10:1)