HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl (chloroformyl)acetate → Ethyl 7-(2-methoxyethoxy)imidazo[1,2-a]pyridine-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl (chloroformyl)acetate | HCID 118030 | — |
| Reactant | 4-(2-Methoxyethoxy)pyridin-2-amine | HCID 66782042 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Ethyl 7-(2-methoxyethoxy)imidazo[1,2-a]pyridine-3-carboxylate | HCID 66782057 | 57% |
Reaction Steps
Ethyl 2-chloro-3-oxopropanoate (5.1 g, 33.9 mmol, Heterocycles 1991, pg. 699) and 4-(2-methoxyethoxy)pyridin-2-amine (5.70 g, 33.9 mmol) was dissolved in EtOH (50 mL) and heated to reflux overnight. The crude reaction mixture was concentrated and purified by flash column chromatography (EtOAc/MeOH 10:0 to 10:1) provided the desired product (57%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08138181B2 |
| Source dataset | uspto-grants-2012_03 |
| ORD ID | ord-c1b4fdccede64e9ea059f495898ba990 |
| Source note | uspto-grants-2012_03 |