HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 7-(2-Methoxyethoxy)imidazo[1,2-a]pyridine-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | Ethyl 7-(2-methoxyethoxy)imidazo[1,2-a]pyridine-3-carboxylate | HCID 66782057 | — |
| Solvent | Tetrahydrofuran ethanol | HCID 21873804 | — |
| Product | 7-(2-Methoxyethoxy)imidazo[1,2-a]pyridine-3-carboxylic acid | HCID 66782025 | — |
Reaction Steps
To ethyl 7-(2-methoxyethoxy)imidazo[1,2-a]pyridine-3-carboxylate (5.01 g, 19.0 mmol) in THF/EtOH (32/6 mL) was added lithium hydroxide (37.9 ml, 37.9 mmol), and the reaction was stirred overnight. HCl (57 mmol, 2M in ether) was added to the mixture, followed by concentration to give the desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08138181B2 |
| Source dataset | uspto-grants-2012_03 |
| ORD ID | ord-e8e0a21380e44f10adf5fea77d2224a8 |
| Source note | uspto-grants-2012_03 |