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HRID1095698

反应详情

EQUATION

反应方程式

HRID 1095698 的结构方程式

REACTANTS

反应物

3
结构：O=C([O-])[O-].[K+].[K+]
HCID11430

Potassium Carbonate

CK2O3

结构：[C-]#[N+]CS(=O)(=O)c1ccc(C)cc1
HCID161915

Tosylmethyl isocyanide

C9H9NO2S

结构：COCCOc1ccn2c(-c3cc(C=O)c4cccc(OC)c4n3)cnc2c1
HCID86638607

未命名化合物

PRODUCTS

生成物

1
结构：COCCOc1ccn2c(-c3cc(-c4cnco4)c4cccc(OC)c4n3)cnc2c1
HCID66781947

未命名化合物

收率 73%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CO
溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

To 8-Methoxy-2-(7-(2-methoxyethoxy)imidazo[1,2-a]pyridin-3-yl)quinoline-4-carbaldehyde (210 mg, 0.556 mmol) and 1-(isocyanomethylsulfonyl)-4-methylbenzene (130 mg, 0.668 mmol) in MeOH (5 mL) was added K2CO3 (154 mg, 1.11 mmol), followed by heating to reflux for 3 hours. The reaction was then cooled to ambient temperature, concentrated and purified by flash column chromatography (EtOAc/MeOH 10:1) providing the desired product (73%). MS APCI (+) m/z 417.2 (M+1) detected.

WORKUP

后处理

  1. temperatureby heating
  2. temperatureto reflux for 3 hours
  3. concentrationconcentrated
  4. custompurified by flash column chromatography (EtOAc/MeOH 10:1)