HRID1095701

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6422

未命名化合物

结构：COCCOc1ccn2c(-c3cc(-c4cnco4)c4cccc(O[C@@H]5CCN(C(=O)OC(C)(C)C)C[C@H]5F)c4n3)cnc2c1

HCID131729510

未命名化合物

PRODUCTS

生成物

结构：COCCOc1ccn2c(-c3cc(-c4cnco4)c4cccc(O[C@@H]5CCNC[C@H]5F)c4n3)cnc2c1

HCID66782186

未命名化合物

收率 60%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

To (trans)-tert-butyl 3-fluoro-4-(2-(7-(2-methoxyethoxy)imidazo[1,2-a]pyridin-3-yl)-4-(oxazol-5-yl)quinolin-8-yloxy)piperidine-1-carboxylate (4 mg, 0.007 mmol) in DCM (1 mL) was added TFA (1 mL), followed by a 30 minute stir. The crude reaction was concentrated and purified by flash column chromatography (DCM/MeOH/NH4OH 10:1:0.1) affording the desired product (60%). MS APCI (+) m/z 504.2 (M+1) detected.

WORKUP

后处理

customThe crude reaction
concentrationwas concentrated
custompurified by flash column chromatography (DCM/MeOH/NH4OH 10:1:0.1)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-88a58a068e9e4949bc7bc4f3bdd715ef
来源数据集: uspto-grants-2012_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08138181B2
来源说明: uspto-grants-2012_03

反应 SMILES

[F:1][C@H:2]1[C@H:7]([O:8][C:9]2[CH:10]=[CH:11][CH:12]=[C:13]3[C:18]=2[N:17]=[C:16]([C:19]2[N:23]4[CH:24]=[CH:25][C:26]([O:28][CH2:29][CH2:30][O:31][CH3:32])=[CH:27][C:22]4=[N:21][CH:20]=2)[CH:15]=[C:14]3[C:33]2[O:37][CH:36]=[N:35][CH:34]=2)[CH2:6][CH2:5][N:4](C(OC(C)(C)C)=O)[CH2:3]1.C(O)(C(F)(F)F)=O>C(Cl)Cl>[F:1][C@H:2]1[C@H:7]([O:8][C:9]2[CH:10]=[CH:11][CH:12]=[C:13]3[C:18]=2[N:17]=[C:16]([C:19]2[N:23]4[CH:24]=[CH:25][C:26]([O:28][CH2:29][CH2:30][O:31][CH3:32])=[CH:27][C:22]4=[N:21][CH:20]=2)[CH:15]=[C:14]3[C:33]2[O:37][CH:36]=[N:35][CH:34]=2)[CH2:6][CH2:5][NH:4][CH2:3]1