反应详情

温度

115 °C

Sodium azide (4.045 g, 62.22 mmol) was added to a solution of (trans)-tert-butyl 3-fluoro-4-(methylsulfonyloxy)piperidine-1-carboxylate (3.700 g, 12.44 mmol) dissolved in DMF (25 mL). The reaction was heated to 115° C. for 24 hours. The mixture was cooled and diluted with water and methylene chloride. After separation, the organic layer was dried over Na2SO, filtered and concentrated in vacuo to provide the desired product (quantitative yield).

1. temperatureThe mixture was cooled
2. customAfter separation
3. dry with materialthe organic layer was dried over Na2SO
4. filtrationfiltered
5. concentrationconcentrated in vacuo