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HRID1095805

反应详情

EQUATION

反应方程式

HRID 1095805 的结构方程式

REACTANTS

反应物

2
结构：[NH4+].[OH-]
HCID14923

Ammonium hydroxide

H5NO

2 次

结构：COc1ccc2c(Nc3c(Cl)cncc3Cl)cc(=O)[nH]c2c1OCCCCCCCl
HCID59268117

未命名化合物

2 次

PRODUCTS

生成物

1
结构：COc1ccc2c(Nc3c(Cl)cncc3Cl)cc(=O)[nH]c2c1OCCCCCCN
HCID53346473

未命名化合物

PROCEDURE

实验过程

The title compound was prepared from 8-(6-chlorohexyloxy)-4-(3,5-dichloropyridin-4-ylamino)-7-methoxyquinolin-2(1H)-one (Intermediate 4) and 28% ammonium hydroxide following the procedure outlined in Example 18, Step 2 (modifications: 40° C., 24 h, then second aliquot of NH4OH added, then 60° C., 24 h).

WORKUP

后处理

  1. custom60° C., 24 h