4-Ethyl-9-(4-hydroxyphenyl)-1-oxa-4,9-diazaspiro[5,5]undecan-3-one → 1-(3-Bromopropyl)piperidine Hydrobromide

HRID 1095826Notes

Reaction equation

HRID 1095826 reaction equation
C(N1CC2(CCN(C3C=CC(O)=CC=3)CC2)OCC1=O)C.Br.[Br:23][CH2:24][CH2:25][CH2:26][N:27]1[CH2:32][CH2:31][CH2:30][C@H:29](C)[CH2:28]1>>[BrH:23].[Br:23][CH2:24][CH2:25][CH2:26][N:27]1[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]1

Participants

3

Reactant 2

HCID 667832714-Ethyl-9-(4-hydroxyphenyl)-1-oxa-4,9-diazaspiro[5,5]undecan-3-oneHCID 66784168(3S)-1-(3-bromopropyl)-3-methylpiperidine hydrobromide

Product 1

HCID 201357721-(3-Bromopropyl)piperidine Hydrobromide

Procedure

The entitled compound was obtained as a pale yellow solid, according to the same method as in Example 5-(c) or according to a method similar to it but using 4-ethyl-9-(4-hydroxyphenyl)-1-oxa-4,9-diazaspiro[5,5]undecan-3-one obtained in Example 5-3-(b), and (3S)-1-(3-bromopropyl)-3-methylpiperidine hydrobromide obtained in Reference Example 4 in place of 1-(3-bromopropyl)piperidine hydrobromide.

Workup

  1. customThe entitled compound was obtained as a pale yellow solid

Sources & evidence

ORD record
ord-271f5b1d857040b19f3a0e667364b4cc
Source dataset
uspto-grants-2012_03
Patent number
US08138206B2

Reaction notes

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