Boron tribromide dichloromethane → HCID 66783669, compound

HRID 1095827Notes

Reaction equation

HRID 1095827 reaction equation
C[O:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]2[CH2:25][CH2:24][C:12]3([O:16][C:15](=[O:17])[N:14]([C:18]4[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=4)[CH2:13]3)[CH2:11][CH2:10]2)=[CH:5][CH:4]=1.B(Br)(Br)Br.ClCCl>C(Cl)(Cl)Cl>[OH:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]2[CH2:10][CH2:11][C:12]3([O:16][C:15](=[O:17])[N:14]([C:18]4[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=4)[CH2:13]3)[CH2:24][CH2:25]2)=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 22277759Boron tribromide dichloromethaneHCID 66783822HCID 66783822, compound

Product 1

HCID 66783669HCID 66783669, compoundYield 28%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

The methoxy compound (1.15 g, 3.39 mmol) obtained in (a) was dissolved in chloroform, and processed with 1.0 M boron tribromide/dichloromethane solution (11 ml, 11 mmol) at 0° C. according to the same method as in Example 5-(b) or according to a method similar to it, thereby obtaining the entitled compound as a crude product (308 mg, 28%).

Sources & evidence

ORD record
ord-ca2215e07f2743299ad7fefedacb1b59
Source dataset
uspto-grants-2012_03
Patent number
US08138206B2

Reaction notes

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