Potassium Carbonate → HCID 46940817, compound

HRID 1095877Notes

Reaction equation

HRID 1095877 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([OH:23])[CH:5]=[CH:6][C:7]=1[CH:8]([CH3:22])[C:9]([C:15]1[CH:20]=[CH:19][N:18]=[C:17]([Cl:21])[CH:16]=1)([OH:14])[C:10]([F:13])([F:12])[F:11].[CH2:24]([O:26][C:27](=[O:36])[C:28]1[CH:33]=[CH:32][C:31]([CH2:34]Br)=[CH:30][CH:29]=1)[CH3:25].C(=O)([O-])[O-].[K+].[K+]>>[CH2:24]([O:26][C:27](=[O:36])[C:28]1[CH:33]=[CH:32][C:31]([CH2:34][O:23][C:4]2[CH:5]=[CH:6][C:7]([CH:8]([CH3:22])[C:9]([C:15]3[CH:20]=[CH:19][N:18]=[C:17]([Cl:21])[CH:16]=3)([OH:14])[C:10]([F:13])([F:12])[F:11])=[C:2]([Cl:1])[CH:3]=2)=[CH:30][CH:29]=1)[CH3:25]

Participants

4

Reactant 3

HCID 11430Potassium CarbonateHCID 954261Ethyl 4-(bromomethyl)benzoateHCID 574212643-Chloro-4-[2-(2-chloro-pyridin-4-yl)-3,3,3-trifluoro-2-hydroxy-1-methyl-propyl]-phenol

Product 1

HCID 46940817HCID 46940817, compound

Procedure

In analogy to Example 1, step 7, 3-chloro-4-[2-(2-chloro-pyridin-4-yl)-3,3,3-trifluoro-2-hydroxy-1-methyl-propyl]-phenol (Example 19, Step 5) was reacted with ethyl-4-(bromomethyl)benzoate and potassium carbonate to give the title compound as a colorless viscous oil. MS (m/e, ISP neg. ion)=528.3 [M−H−].

Sources & evidence

ORD record
ord-2d7e12d236f9496d8ff81ca85b9ccbfc
Source dataset
uspto-grants-2012_03
Patent number
US08138189B2

Reaction notes

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