反应详情

A mixture of 4-((E)-2-{3-chloro-4-[3,3,3-trifluoro-2-hydroxy-1-methyl-2-(2-methyl-pyridin-4-yl)-propyl]-phenyl}-vinyl)-benzoic acid (Example 66, 12 mg) and palladium/aluminum oxide (0.3 mg) in EtOAc (2.5 ml) was stirred overnight under a hydrogen atmosphere. The mixture was filtered and concentrated to give the title compound (2 mg) as light brown oil. MS (m/e)=478.1 [M+H+].

1. filtrationThe mixture was filtered
2. concentrationconcentrated