6-Bromomethyl-nicotinic acid methyl ester → HCID 59508739, compound

HRID 1095936Notes

Reaction equation

HRID 1095936 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([OH:23])[CH:5]=[CH:6][C:7]=1[CH:8]([CH3:22])[C:9]([C:15]1[CH:20]=[CH:19][N:18]=[C:17]([Cl:21])[CH:16]=1)([OH:14])[C:10]([F:13])([F:12])[F:11].[CH3:24][O:25][C:26](=[O:35])[C:27]1[CH:32]=[CH:31][C:30]([CH2:33]Br)=[N:29][CH:28]=1>>[CH3:24][O:25][C:26](=[O:35])[C:27]1[CH:32]=[CH:31][C:30]([CH2:33][O:23][C:4]2[CH:5]=[CH:6][C:7]([CH:8]([CH3:22])[C:9]([C:15]3[CH:20]=[CH:19][N:18]=[C:17]([Cl:21])[CH:16]=3)([OH:14])[C:10]([F:13])([F:12])[F:11])=[C:2]([Cl:1])[CH:3]=2)=[N:29][CH:28]=1

Participants

3

Reactant 2

HCID 127522376-Bromomethyl-nicotinic acid methyl esterHCID 574212643-Chloro-4-[2-(2-chloro-pyridin-4-yl)-3,3,3-trifluoro-2-hydroxy-1-methyl-propyl]-phenol

Product 1

HCID 59508739HCID 59508739, compound

Procedure

The title compound was prepared in analogy to Example 93, step 7 from 3-chloro-4-[2-(2-chloro-pyridin-4-yl)-3,3,3-trifluoro-2-hydroxy-1-methyl-propyl]-phenol (obtained in Example 19, step 5) by alkylation with methyl-6-(bromomethyl)-nicotinate [CAS Reg. No. 131803-48-0]. MS (m/e)=515.0 [MH+].

Sources & evidence

ORD record
ord-9902d198a6664311a7bc92d7459c7548
Source dataset
uspto-grants-2012_03
Patent number
US08138189B2

Reaction notes

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