HRID1095962

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(c1ccc(O)cc1Cl)C(O)(c1cnc2ccccc2c1)C(F)(F)F

HCID57421299

未命名化合物

HCID57443306

未命名化合物

PRODUCTS

生成物

结构：COC(=O)C1(c2ccc(COc3ccc(C(C)C(O)(c4cnc5ccccc5c4)C(F)(F)F)c(Cl)c3)cc2)CC1

HCID66699386

未命名化合物

PROCEDURE

实验过程

In analogy to Example 140, step 6, 3-chloro-4-(3,3,3-trifluoro-2-hydroxy-1-methyl-2-quinolin-3-yl-propyl)-phenol (Example 140, step 5) was reacted with 1-(4-bromomethyl-phenyl)-cyclopropanecarboxylic acid methyl ester (CAS 873372-30-6) to give the title compound as an off-white solid. MS (m/e)=570.4 [M+H+].

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-f3170fcf2099472fa1bdd7b119972cf2
来源数据集: uspto-grants-2012_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08138189B2
来源说明: uspto-grants-2012_03

反应 SMILES

[Cl:1][C:2]1[CH:3]=[C:4]([OH:26])[CH:5]=[CH:6][C:7]=1[CH:8]([CH3:25])[C:9]([OH:24])([C:14]1[CH:15]=[N:16][C:17]2[C:22]([CH:23]=1)=[CH:21][CH:20]=[CH:19][CH:18]=2)[C:10]([F:13])([F:12])[F:11].[CH3:27][O:28][C:29]([C:31]1([C:34]2[CH:39]=[CH:38][C:37]([CH2:40]Br)=[CH:36][CH:35]=2)[CH2:33][CH2:32]1)=[O:30]>>[CH3:27][O:28][C:29]([C:31]1([C:34]2[CH:35]=[CH:36][C:37]([CH2:40][O:26][C:4]3[CH:5]=[CH:6][C:7]([CH:8]([CH3:25])[C:9]([OH:24])([C:14]4[CH:15]=[N:16][C:17]5[C:22]([CH:23]=4)=[CH:21][CH:20]=[CH:19][CH:18]=5)[C:10]([F:11])([F:13])[F:12])=[C:2]([Cl:1])[CH:3]=3)=[CH:38][CH:39]=2)[CH2:33][CH2:32]1)=[O:30]