HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Chloro-4-(3,3,3-trifluoro-2-hydroxy-1-methyl-2-quinolin-3-yl-propyl)-phenol → 1-{4-[3-Chloro-4-(3,3,3-trifluoro-2-hydroxy-1-methyl-2-quinolin-3-yl-propyl)-phenoxymethyl]-phenyl}-cyclopropanecarboxylic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Chloro-4-(3,3,3-trifluoro-2-hydroxy-1-methyl-2-quinolin-3-yl-propyl)-phenol | HCID 57421299 | — |
| Reactant | Methyl 1-(4-(bromomethyl)phenyl)cyclopropanecarboxylate | HCID 57443306 | — |
| Product | 1-{4-[3-Chloro-4-(3,3,3-trifluoro-2-hydroxy-1-methyl-2-quinolin-3-yl-propyl)-phenoxymethyl]-phenyl}-cyclopropanecarboxylic acid methyl ester | HCID 66699386 | — |
Reaction Steps
In analogy to Example 140, step 6, 3-chloro-4-(3,3,3-trifluoro-2-hydroxy-1-methyl-2-quinolin-3-yl-propyl)-phenol (Example 140, step 5) was reacted with 1-(4-bromomethyl-phenyl)-cyclopropanecarboxylic acid methyl ester (CAS 873372-30-6) to give the title compound as an off-white solid. MS (m/e)=570.4 [M+H+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08138189B2 |
| Source dataset | uspto-grants-2012_03 |
| ORD ID | ord-f3170fcf2099472fa1bdd7b119972cf2 |
| Source note | uspto-grants-2012_03 |