HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 5-[2-(4-Bromo-2-chloro-phenyl)-1-hydroxy-1-trifluoromethyl-propyl]-1H-pyridin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 3-(4-Bromo-2-chloro-phenyl)-1,1,1-trifluoro-2-(6-methoxy-pyridin-3-yl)-butan-2-ol | HCID 57421321 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 5-[2-(4-Bromo-2-chloro-phenyl)-1-hydroxy-1-trifluoromethyl-propyl]-1H-pyridin-2-one | HCID 57421322 | — |
Reaction Steps
In analogy to Example 182, step 2, 3-(4-bromo-2-chloro-phenyl)-1,1,1-trifluoro-2-(6-methoxy-pyridin-3-yl)-butan-2-ol (Example 175, step 3) was converted to the title compound by treatment with concentrated HCl in dioxane. Colorless solid. MS (m/e)=410.1 [M+H+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08138189B2 |
| Source dataset | uspto-grants-2012_03 |
| ORD ID | ord-3c947b0a17184a8288613c53701f620f |
| Source note | uspto-grants-2012_03 |