Hydrochloric Acid → 5-[2-(4-Bromo-2-chloro-phenyl)-1-hydroxy-1-trifluoromethyl-propyl]-1H-pyridin-2-one

HRID 1096001Notes

Reaction equation

HRID 1096001 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([CH3:23])[C:9]([C:15]2[CH:16]=[N:17][C:18]([O:21]C)=[CH:19][CH:20]=2)([OH:14])[C:10]([F:13])([F:12])[F:11])=[C:4]([Cl:24])[CH:3]=1.Cl>O1CCOCC1>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([CH3:23])[C:9]([C:15]2[CH:20]=[CH:19][C:18](=[O:21])[NH:17][CH:16]=2)([OH:14])[C:10]([F:13])([F:11])[F:12])=[C:4]([Cl:24])[CH:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 574213213-(4-Bromo-2-chloro-phenyl)-1,1,1-trifluoro-2-(6-methoxy-pyridin-3-yl)-butan-2-ol

Product 1

HCID 574213225-[2-(4-Bromo-2-chloro-phenyl)-1-hydroxy-1-trifluoromethyl-propyl]-1H-pyridin-2-one

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

In analogy to Example 182, step 2, 3-(4-bromo-2-chloro-phenyl)-1,1,1-trifluoro-2-(6-methoxy-pyridin-3-yl)-butan-2-ol (Example 175, step 3) was converted to the title compound by treatment with concentrated HCl in dioxane. Colorless solid. MS (m/e)=410.1 [M+H+].

Sources & evidence

ORD record
ord-3c947b0a17184a8288613c53701f620f
Source dataset
uspto-grants-2012_03
Patent number
US08138189B2

Reaction notes

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