Cesium carbonate → HCID 86645958, compound

HRID 1096032Notes

Reaction equation

HRID 1096032 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([OH:8])[CH:5]=[CH:4][C:3]=1[CH:9]([CH3:24])[C:10]([C:16]1[CH:17]=[CH:18][C:19](=[O:23])[N:20]([CH3:22])[CH:21]=1)([OH:15])[C:11]([F:14])([F:13])[F:12].F[C:26]1[CH:33]=[CH:32][C:29]([CH:30]=[O:31])=[C:28]([C:34]([F:37])([F:36])[F:35])[CH:27]=1.C(=O)([O-])[O-].[Cs+].[Cs+]>>[Cl:1][C:2]1[CH:7]=[C:6]([CH:5]=[CH:4][C:3]=1[CH:9]([CH3:24])[C:10]([OH:15])([C:16]1[CH:17]=[CH:18][C:19](=[O:23])[N:20]([CH3:22])[CH:21]=1)[C:11]([F:13])([F:14])[F:12])[O:8][C:26]1[CH:33]=[CH:32][C:29]([CH:30]=[O:31])=[C:28]([C:34]([F:35])([F:37])[F:36])[CH:27]=1

Participants

4

Reactant 3

HCID 10796Cesium carbonateHCID 5229404-Fluoro-2-(trifluoromethyl)benzaldehydeHCID 574213145-[2-(2-Chloro-4-hydroxy-phenyl)-1-hydroxy-1-trifluoromethyl-propyl]-1-methyl-1H-pyridin-2-one

Product 1

HCID 86645958HCID 86645958, compound

Procedure

In analogy to Example 214, step 1, 5-[2-(2-chloro-4-hydroxy-phenyl)-1-hydroxy-1-trifluoromethyl-propyl]-1-methyl-1H-pyridin-2-one(Example 151, step 7) was reacted with 4-fluoro-2-(trifluoromethyl)benzaldehyde in the presence of cesium carbonate to give the title compound as a colorless oil. MS (m/e, ISP neg. ion)=532.0 [M−H+].

Sources & evidence

ORD record
ord-4a9f5c05e5fc44cf8a9994b5c2137e24
Source dataset
uspto-grants-2012_03
Patent number
US08138189B2

Reaction notes

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