HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cesium carbonate → HCID 86645958, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 4-Fluoro-2-(trifluoromethyl)benzaldehyde | HCID 522940 | — |
| Reactant | 5-[2-(2-Chloro-4-hydroxy-phenyl)-1-hydroxy-1-trifluoromethyl-propyl]-1-methyl-1H-pyridin-2-one | HCID 57421314 | — |
| Product | HCID 86645958 | HCID 86645958 | — |
Reaction Steps
In analogy to Example 214, step 1, 5-[2-(2-chloro-4-hydroxy-phenyl)-1-hydroxy-1-trifluoromethyl-propyl]-1-methyl-1H-pyridin-2-one(Example 151, step 7) was reacted with 4-fluoro-2-(trifluoromethyl)benzaldehyde in the presence of cesium carbonate to give the title compound as a colorless oil. MS (m/e, ISP neg. ion)=532.0 [M−H+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08138189B2 |
| Source dataset | uspto-grants-2012_03 |
| ORD ID | ord-4a9f5c05e5fc44cf8a9994b5c2137e24 |
| Source note | uspto-grants-2012_03 |