Boron tribromide → HCID 66699206, compound

HRID 1096034Notes

Reaction equation

[Cl:1][C:2]1[C:3](=[O:26])[N:4]([CH3:25])[CH:5]=[C:6]([C:8]([OH:24])([C:20]([F:23])([F:22])[F:21])[CH:9]([C:11]2[CH:16]=[CH:15][C:14]([O:17]C)=[CH:13][C:12]=2[Cl:19])[CH3:10])[CH:7]=1.B(Br)(Br)Br>>[Cl:1][C:2]1[C:3](=[O:26])[N:4]([CH3:25])[CH:5]=[C:6]([C:8]([OH:24])([C:20]([F:22])([F:23])[F:21])[CH:9]([C:11]2[CH:16]=[CH:15][C:14]([OH:17])=[CH:13][C:12]=2[Cl:19])[CH3:10])[CH:7]=1

Participants

Reactant 2

HCID 25134Boron tribromide

HCID 66699404HCID 66699404, compound

Product 1

HCID 66699206HCID 66699206, compound

Procedure

In analogy to Example 147, step 5, 3-chloro-5-[2-(2-chloro-4-methoxy-phenyl)-1-hydroxy-1-trifluoromethyl-propyl]-1-methyl-1H-pyridin-2-one was reacted with BBr3 to give the title compound as an off-white solid. MS (m/e, ISP neg. ion)=393.8 [M−H+].

Sources & evidence

ORD record: ord-32d2bd4f4f6a4059b2233d73940f52e1
Source dataset: uspto-grants-2012_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08138189B2

Reaction notes

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