Dabco → HCID 66782416, compound

Participants

Reaction Steps

In analogy to Example 163, 5-[2-(2,3-dichloro-4-hydroxy-phenyl)-1-hydroxy-1-trifluoromethyl-propyl]-1-methyl-1H-pyridin-2-one (Example 197, step 5; 150 mg, 0.38 mmol) was reacted with methyl-5-chloro-2-pyridazinecarboxylate (67 mg, 0.38 mmol), 0.069 ml TEA and 6 mg DABCO in 2 ml DMF for 4 h at rt to give 184 mg of the title compound as an off-white solid. MS (M+H+)=532.1

Provenance & Evidence