Dabco → HCID 66782416, compound

HRID 1096042Notes

Reaction equation

HRID 1096042 reaction equation
[Cl:1][C:2]1[C:7]([Cl:8])=[C:6]([OH:9])[CH:5]=[CH:4][C:3]=1[CH:10]([CH3:25])[C:11]([C:17]1[CH:18]=[CH:19][C:20](=[O:24])[N:21]([CH3:23])[CH:22]=1)([OH:16])[C:12]([F:15])([F:14])[F:13].[CH3:26][O:27][C:28](N1C=CC(Cl)=CN1)=[O:29].[CH2:37]1[N:42]2CC[N:39]([CH2:40][CH2:41]2)[CH2:38]1>CN(C=O)C>[CH3:26][O:27][C:28]([C:40]1[CH:41]=[N:42][C:37]([O:9][C:6]2[CH:5]=[CH:4][C:3]([CH:10]([CH3:25])[C:11]([OH:16])([C:17]3[CH:18]=[CH:19][C:20](=[O:24])[N:21]([CH3:23])[CH:22]=3)[C:12]([F:15])([F:13])[F:14])=[C:2]([Cl:1])[C:7]=2[Cl:8])=[CH:38][N:39]=1)=[O:29]

Participants

5

Reactant 3

HCID 9237DabcoHCID 57421326HCID 57421326, compoundHCID 66699176HCID 66699176, compound

Product 1

HCID 66782416HCID 66782416, compoundYield 646.3%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

In analogy to Example 163, 5-[2-(2,3-dichloro-4-hydroxy-phenyl)-1-hydroxy-1-trifluoromethyl-propyl]-1-methyl-1H-pyridin-2-one (Example 197, step 5; 150 mg, 0.38 mmol) was reacted with methyl-5-chloro-2-pyridazinecarboxylate (67 mg, 0.38 mmol), 0.069 ml TEA and 6 mg DABCO in 2 ml DMF for 4 h at rt to give 184 mg of the title compound as an off-white solid. MS (M+H+)=532.1

Sources & evidence

ORD record
ord-5f79865d192e43198f9a3c60db7c0a3f
Source dataset
uspto-grants-2012_03
Patent number
US08138189B2

Reaction notes

Loading…