Hydrochloric Acid → HCID 178480693, compound

HRID 1096159Notes

Reaction equation

HRID 1096159 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:8]2[CH:31]=[CH:30][C:11]([C:12]([NH:14][C:15]3[C:16]4[CH:22]=[C:21]([C:23]([O:25]C(C)(C)C)=[O:24])[S:20][C:17]=4[NH:18][N:19]=3)=[O:13])=[CH:10][CH:9]=2)[CH2:4][CH2:3]1.[ClH:32]>O1CCOCC1>[ClH:32].[CH3:1][N:2]1[CH2:3][CH2:4][N:5]([C:8]2[CH:9]=[CH:10][C:11]([C:12]([NH:14][C:15]3[C:16]4[CH:22]=[C:21]([C:23]([OH:25])=[O:24])[S:20][C:17]=4[NH:18][N:19]=3)=[O:13])=[CH:30][CH:31]=2)[CH2:6][CH2:7]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178480694HCID 178480694, compound

Product 1

HCID 178480693HCID 178480693, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A mixture of tert-butyl 3-{[4-(4-methylpiperazin-1-yl)benzoyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxylate (0.50 g, 1.1 mmol) in hydrochloric acid 4M in dioxane (15 mL) was stirred for 16 hours at room temperature. Afterward, volatiles were removed by evaporation under reduced pressure and the residue was triturated with ethyl ether to give 0.496 g of the title compound as a white solid.

Workup

  1. customAfterward, volatiles were removed by evaporation under reduced pressure
  2. customthe residue was triturated with ethyl ether

Sources & evidence

ORD record
ord-98efcaf6c3d1422b923465bbd2205884
Source dataset
uspto-grants-2012_03
Patent number
US08138217B2

Reaction notes

Loading…