HuagongsheHuagongshe Chemistry Print Report · For research reference only
(4S)-6-Azaspiro[2.5]octan-4-ol → Hydrochloric Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (4S)-6-Azaspiro[2.5]octan-4-ol | HCID 44541813 | — |
| Reactant | (S)-2-[4-(3-chloro-phenyl)-7-oxo-[1,4]diazepan-1-yl]-4-oxo-butyric acid methyl ester | HCID 86638380 | — |
| Product | Hydrochloric Acid | HCID 313 | — |
| Product | (S)-2-[4-(3-Chloro-phenyl)-7-oxo-[1,4]diazepan-1-yl]-4-((S)-4-hydroxy-6-aza-spiro[2.5]oct-6-yl)-butyric Acid methyl ester | HCID 59159253 | — |
Reaction Steps
In analogy to the procedure described in example 1K, (S)-2-[4-(3-chloro-phenyl)-7-oxo-[1,4]diazepan-1-yl]-4-oxo-butyric acid methyl ester and (S)-6-aza-spiro[2.5]octan-4-ol; hydrochloride (intermediate 2) gave the title compound as light yellow foam. MS: 450.3 (MH+, 1Cl).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08138175B2 |
| Source dataset | uspto-grants-2012_03 |
| ORD ID | ord-f20a309fcfda4a1bb2ebd5035412f604 |
| Source note | uspto-grants-2012_03 |