(4S)-6-Azaspiro[2.5]octan-4-ol → Hydrochloric Acid

HRID 1096203Notes

Reaction equation

HRID 1096203 reaction equation
[CH3:1][O:2][C:3](=[O:23])[C@@H:4]([N:8]1[C:14](=[O:15])[CH2:13][CH2:12][N:11]([C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([Cl:22])[CH:17]=2)[CH2:10][CH2:9]1)[CH2:5][CH:6]=O.[CH2:24]1[C:26]2([CH2:31][CH2:30][NH:29][CH2:28][C@H:27]2[OH:32])[CH2:25]1>>[ClH:22].[CH3:1][O:2][C:3](=[O:23])[C@@H:4]([N:8]1[C:14](=[O:15])[CH2:13][CH2:12][N:11]([C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([Cl:22])[CH:17]=2)[CH2:10][CH2:9]1)[CH2:5][CH2:6][N:29]1[CH2:30][CH2:31][C:26]2([CH2:24][CH2:25]2)[C@H:27]([OH:32])[CH2:28]1

Participants

4

Reactant 2

HCID 44541813(4S)-6-Azaspiro[2.5]octan-4-olHCID 86638380(S)-2-[4-(3-chloro-phenyl)-7-oxo-[1,4]diazepan-1-yl]-4-oxo-butyric acid methyl ester

Product 2

HCID 313Hydrochloric AcidHCID 59159253(S)-2-[4-(3-Chloro-phenyl)-7-oxo-[1,4]diazepan-1-yl]-4-((S)-4-hydroxy-6-aza-spiro[2.5]oct-6-yl)-butyric Acid methyl ester

Procedure

In analogy to the procedure described in example 1K, (S)-2-[4-(3-chloro-phenyl)-7-oxo-[1,4]diazepan-1-yl]-4-oxo-butyric acid methyl ester and (S)-6-aza-spiro[2.5]octan-4-ol; hydrochloride (intermediate 2) gave the title compound as light yellow foam. MS: 450.3 (MH+, 1Cl).

Sources & evidence

ORD record
ord-f20a309fcfda4a1bb2ebd5035412f604
Source dataset
uspto-grants-2012_03
Patent number
US08138175B2

Reaction notes

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